A Facile Synthesis of 4-Alkyl-2-Quinolones

作     者：Huang Xian and Ye Fangchen (Department of Chemistry, Hangzhou University, Hangzhou) 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：1992年第8卷第1期

页      面：45-47页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：Supported by the National Natural Science Foundation of China 

主　　题：Quinolones Meldrum' s acid Acylation Aminolysis Synthesis 

摘      要：The derivatives of 4-alkyl-2-quinolones possess a variety of biological activities. The general synthetic method of 4-alkyl-2-quinolones is the reaction of aryl amines with β-ketoesters to form β-ketoamides, which are then heated in concentrated sulfuric acid to complete the ring closure. Although a number of its 4-methyl and aryl derivatives have been obtained, other 4-alkyl-2-quinolones are rarely mentioned for lack of a convenient method to prepare the appropriate β-ketoesters used in condensation.