Effect of Lichong decoction on expression of Bcl-2 and Bcl-2-associated X protein mRNAs in hysteromyoma model rat

作     者：Donghua Li Xin Xu Ruiya Qian Jianguo Geng Yan Zhang Xiaolei Xie Yasong Wang Xiaoli Zou 

作者机构：School of Traditional Chinese MedicineCapital Medical University Beijing Hospital ofTraditional Chinese Medicine Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing Maternaland Child Health Care HospitalBeijing 100026China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2013年第33卷第2期

页      面：238-242页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by Beijing City Natural Science Fund (No.7082015) National Natural Science Fund (No. 81073096) "Middle-young Aged Core Talent Cultural Plant" of Beijing City University Talent Strengthening Education Plant (No.PHR201008403) 

主　　题：Myoma Apoptosis Genes, bcl-2 Bcl-2-associated X protein Lichong decoction 

摘      要：OBJECTIVE:To study on effects of Lichong decoction on expression of apoptosis-controlling genes,Bcl-2 and Bcl-2-associated X protein(Bax) mRNAs in hysteromyoma tissue of the hysteromyoma model ***:Fifty Wistar female rats were randomly divided into a normal group,a model group,a Lichong decoction group,a Guizifuling capsule group and a Mifepristone *** hysteromyoma rat model was established by intraperitoneal injection of exogenous estrin and *** examination of uterine tissue,uterine coefficient and uterine transverse diameter were made under optic microscope and expressions of Bcl-2 and Bax mRNAs in uterine tissue in the groups were detected with real-time fluorescent quantitative polymerase chain reaction(PCR) ***:After treatment,under microscope it was found that in the Lichong decoction group myometrium thinned,muscle fiber slightly overgrowth or long and thin,regular arrangement,inserting phenomenon of inner circular muscle and external longitudinal muscle was occasionally or not seen in the Lichong decoction *** uterine coefficient and the uterine transverse diameter significantly decreased(P0.01),and Bcl-2 mRNA expression significantly decreased(P0.01) and Bax mRNA expression significantly increased in hysteromyoma tissue(P0.01) in the Lichong decoction group as compared with the model ***:Therapeutic effects of Lichong decoction on hysteromyoma is related with decrease of Bcl-2 mRNA expression and increase of Bax mRNA expression.