Geraniol alleviates cyclophosphamide-induced cardiotoxicity in mice

作     者：Shahid Karim Rasheed A.Shaik Shahid Karim;Rasheed A.Shaik

作者机构：Department of Clinical PharmacologyFaculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Pharmacology and ToxicologyFaculty of PharmacyKing Abdulaziz UniversityJeddahSaudi Arabia 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2024年第14卷第10期

页      面：427-435页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：The Deanship of Scientific Research at King Abdulaziz University Jeddah Saudi Arabia has funded this project under grant no.RG-21-166-43 

主　　题：Geraniol Cardiotoxicity Natural product Cyclophosphamide Inflammation Apoptosis 

摘      要：Objective:To explore the effect of geraniol on cyclophosphamide-induced ***:Mice were divided into five groups:the control group,the cyclophosphamide group(200 mg/kg cyclophosphamide,*** day 7),the group treated with geraniol 100 and 200 mg/kg from day 1 to day 14,along with a single dose of cyclophosphamide on day 7,and the geraniol alone group(200 mg/kg geraniol from day 1 to day 14).At the end of the study,animals were sacrificed,and blood and heart were collected and analyzed for biochemical,histopathological,and immunohistochemical ***:Treatment with 200 mg/kg geraniol significantly reduced the levels of cardiac injury markers,malondialdehyde,and inflammatory and apoptotic markers,while increasing antioxidant activities in mice with cyclophosphamide-induced ***,it remarkably alleviated histopathological aberrations in cardiac ***:Geraniol attenuates cyclophosphamide-induced cardiotoxicity via antioxidant,anti-inflammatory,and antiapoptotic effects.