Mouse Models for the Study of Liver Fibrosis Regression In Vivo and Ex Vivo
作者机构：Division of EndocrinologyDepartment of MedicineLeiden University Medical CenterLeidenThe Netherlands Einthoven Laboratory for Experimental Vascular MedicineLeiden University Medical CenterLeidenThe Netherlands
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2024年第12卷第11期
页 面：930-938页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Liver fibrosis Liver steatosis Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis Fibrosis regression Mouse models of liver fibrosis
摘 要：This review discussed experimental mouse models used in the pre-clinical study of liver fibrosis regression,a pivotal process in preventing the progression of metabolic dysfunction-associated steatohepatitis to irreversible liver *** models provide a valuable resource for understanding the cellular and molecular processes underlying fibrosis regression in different *** primary focus of this review is on the most commonly used models with diet-or hepatotoxin-induced fibrosis,but it also touches upon genetic models and mouse models with biliary atresia or parasiteinduced *** addition to emphasizing in vivo models,we briefly summarized current in vitro approaches designed for studying fibrosis regression and provided an outlook on evolving methodologies that aim to refine and reduce the number of experimental animals needed for these ***,these models contribute significantly to unraveling the underlying mechanisms of liver fibrosis regression and offer insights into potential therapeutic *** presenting a comprehensive overview of these models and highlighting their respective advantages and limitations,this review serves as a roadmap for future research.
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