Regulator of myeloid differentiation and function:The secret life of Ikaros

作     者：Olivia L Francis Jonathon L Payne Kimberly J Payne 

作者机构：Department of Pathology and Human AnatomyCenter for Health Disparities and Molecular MedicineLoma Linda University School of MedicineMortensen Hall 1st Floor11085 Campus StLoma LindaCA 9350United States Department of Chemistry and BiochemistryLa Sierra University4500 Riverwalk ParkwayRiverside CA 92515United States 

出 版 物：《World Journal of Biological Chemistry》 (世界生物化学杂志（英文版）（电子版）)

年 卷 期：2011年第2卷第6期

页      面：119-125页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Ikaros Myeloid differentiation Lineage commitment Hematopoiesis Post-transcriptional regulation Post-translational regulation 

摘      要：Ikaros (also known as Lyf-1) was initially described as a lymphoid-specific transcription *** Ikaros has been shown to regulate hematopoietic stem cell renewal,as well as the development and function of cells from multiple hematopoietic lineages,including the myeloid lineage,Ikaros has primarily been studied in context of lymphoid development and *** review focuses on the role of Ikaros in myeloid *** address the importance of post-transcriptional regulation of Ikaros function;the emerging role of Ikaros in myeloid malignancy;Ikaros as a regulator of myeloid differentiation and function;and the selective expression of Ikaros isoform-x in cells with myeloid *** highlight the challenges of dissecting Ikaros function in lineage commitment decisions among lymphoidmyeloid progenitors that have emerged as a major myeloid differentiation pathway in recent studies,which leads to reconstruction of the traditional map of murine and human hematopoiesis.