Deep vein thrombosis and pulmonary embolism in cirrhotic patients:Systematic review

作     者：Ashish Aggarwal Kanika Puri Suthat Liangpunsakul 

作者机构：Division of Gastroenterology and HepatologyDepartment of MedicineIndiana University Medical CenterIN 46202United States Division of Gastroenterology and HepatologyDepartment of MedicineIndiana University Medical Center and Roudebush Veterans Administration Medical CenterIndianapolisIN 46202United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第19期

页      面：5737-5745页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Deep venous thrombosis Chronic liver disease Cirrhosis Thrombosis Anticoagulation Pathogenesis Portal vein thrombosis 

摘      要：Patients with liver cirrhosis were traditionally believed to be protected against development of blood ***,studies have shown that these patients may probably be at an increased risk of venous thrombotic *** the hemostatic changes in the chronic liver disease patients and the factors that may predict bleeding vs thrombotic complications remains an area of active research,it is believed that the coagulation cascade is delicately balanced in these patients because of parallel reduced hepatic synthesis of pro and anticoagulant *** state in cirrhotic patients is responsible for not only portal or non-portal thrombosis[deep vein thrombosis(DVT)and pulmonary embolism(PE)];it has also been associated with progression of liver *** use of anticoagulants in cirrhosis patients is a challenging,and often a scary *** review summarizes the current literature on the prevalence of venous thrombosis(DVT and PE),risk factors and safety of prophylactic and therapeutic anticoagulation in patients with chronic liver disease.