Highly oxygenated clerodane furanoditerpenoids from the leaves and twigs of Croton yunnanensis

作     者：WANG Didi MEI Fang NIE Jinchun LI Zhenwei ZHANG Daidi GUO Dean LI Wei 

作者机构：School of Pharmacy Guizhou Medical University Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物(英文版))

年 卷 期：2024年第22卷第10期

页      面：945-954页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (Nos. 82104020 and 82130111) the High-level Innovative Research Institute of Department of Science and Technology of Guangdong Province (No. 2021B0909050003) the High-level New R&D Institute of Department of Science and Technology of Guangdong Province (No. 2019B090904008) 

主　　题：Clerodane furanoditerpenoid Croton yunnanensis Euphorbiaceae NO inhibitory activity 

摘      要：The phytochemical investigation of the leaves and twigs of Croton yunnanensis resulted in the isolation of eight new clerodane furanoditerpenoids, named croyunfuranoids A-H（1-8）, along with three known analogs（9-11）. The structures of these compounds were elucidated using spectroscopic analyses, and their absolute configurations were determined through a combination of electronic circular dichroism（ECD） calculations and single-crystal X-ray diffraction. Notably, Croyunfuranoid D（4） is identified as a rare 18,19-dinor-clerodane diterpenoid. Additionally, the structure of a previously reported diterpenoid, crotonyunnan B, was *** isolated compounds were evaluated for their inhibitory activities on nitric oxide（NO） production in LPS-induced RAW 264.7 macrophages. Among them, compounds 5 and 6 demonstrated significant inhibitory effects, with IC50values of 20.33 ± 2.31 and 22.80 ±1.31 μmol·L-1, respectively.