New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03

作     者：ZHAO Songfeng JING Ziwei 

作者机构：Department of Pharmacy the First Affiliated Hospital of Zhengzhou University 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物(英文版))

年 卷 期：2024年第04期

页      面：356-364页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (No. 82003956) the Henan Young Elite Scientists Sponsorship Program (No. 2023HYTP032) 

摘      要：A comprehensive chemical study of the endophytic fungus Arthrinium sp. ZS03, associated with Acorus tatarinowii Schott, yielded eleven pimarane diterpenoids（compounds 1–11）, including seven novel compounds designated arthrinoids A–G（1–7）.The determination of their structures and absolute configurations was achieved through extensive spectroscopic techniques, quantum chemical calculations of electronic circular dichroism（ECD）, and single-crystal X-ray diffraction analysis. Furthermore, 7 demonstrated inhibitory activity against Klebsiella pneumoniae, comparable to the reference antibiotic amikacin, with a minimum inhibitory concentration（MIC） of 8 μg·mL-1.