Stem cells for the treatment of musculoskeletal pain
为肌与骨的疼痛的治疗的干细胞作者机构：Department of Orthopedic Surgery University Hospital Saint Spiridon 700111 Iasi Romania Department of Clinical Veterinary and Animal Science Faculty of Health and Medical Sciences University of Copenhagen Copenhagen 1870 Frederiksberg Denmark Department of Molecular Genetics and Immunology Grigore T. Popa University of Medicine and Pharmacy 700000 Iasi Romania BioTalentum 2100 Godollo Hungary
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2015年第7卷第1期
页 面：96-105页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
主 题：Molecular biomarkers Musculoskeletal pain Stem cells
摘 要：Musculoskeletal-related pain is one of the most disabling health conditions affecting more than one third of the adult population worldwide. Pain from various mechanisms and origins is currently underdiagnosed and undertreated. The complexity of molecular mechanisms correlating pain and the progression of musculoskeletal diseases is not yet fully understood. Molecular biomarkers for objective evaluation and treatment follow-up are needed as a step towards targeted treatment of pain as a symptom or as a disease. Stem cell therapy is already under investigation for the treatment of different types of musculoskeletalrelated pain. Mesenchymal stem cell-based therapies are already being tested in various clinical trials that use musculoskeletal system-related pain as the primary or secondary endpoint. Genetically engineered stem cells, as well as induced pluripotent stem cells, offer promising novel perspectives for pain treatment. It is possible that a more focused approach and reassessment of therapeutic goals will contribute to the overall efficacy, as well as to the clinical acceptance of regenerative medicine therapies. This article briefly describes the principal types of musculoskeletal-related pain and reviews the stem cell-based therapies that have been specifically designed for its treatment.
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