Membrane resealing as a promising strategy for early treatment of neurotrauma

作     者：Xiaoming Jin 

作者机构：Department of Anatomy and Cell Biology & Stark Neuroscience Research InstituteIndiana Spinal Cord and Brain Injury Research GroupIndiana University School of Medicine320 West 15th StreetIndianapolisIN 46202USA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2014年第9卷第21期

页      面：1876-1877页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：TBI Membrane resealing as a promising strategy for early treatment of neurotrauma 

摘      要：Traumatic injuries to the central nervous system （CNS）, in- cluding traumatic brain injury （TBI） and spinal cord injury （SCI）, often involve an immediate mechanical damage to plas- ma membrane that surrounds neuronal sornata and axons. This initial disruption of plasma membrane following injuries has been convincingly demonstrated by increased membrane permeability to large molecules and dyes that are normally inaccessible to cellular plasma （Farkas et al., 2006; Cho and Borgens, 2012）. Further evidence comes from experiments that showed ultra-structural changes of plasma membranes, axons, and organelles, and subsequent neuronal death and axotomy （Povlishock and Pettus, 1996; Whalen et al., 2008）.