Efficacy and safety of 10 mg/d vs. 20 mg/d rosuvastatin in elderly patients with coronary heart disease and hyperlipidemia

作     者：陈慧钦 

作者机构：The Departerment of Pharmacy Longqiao Street Community Health Service CenterChengxiang District Putian City 

出 版 物：《South China Journal of Cardiology》 (岭南心血管病杂志(英文版))

年 卷 期：2024年第3期

页      面：149-155页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

摘      要：Background Population aging has become a common concern in the world. coronary heart disease(CHD) is one of the major diseases that lead to the death of the elderly and affect the quality of life. Studies have confirmed that increase in blood lipids is an independent risk factor for the occurrence and development of coronary heart disease. Therefore, adjusting the level of blood lipids effectively has significant value to alleviate the severity, slow the progression and reduce the occurrence of complications of coronary heart disease. Statins can play a role in regulating the blood lipids. Although rosuvastatin is a kind of highly potent statin that is often used at present, the effects of different doses of rosuvastatin on elderly patients with coronary heart disease and hyperlipidemia were seldom reported. Methods In this study, 60 elderly patients with coronary heart disease and hyperlipidemia admitted to our hospital from 2021 to July to September 2023 were retrospectively selected. 30 patients with 10 mg/d rosuvastatin were assigned to the control group and 30 patients with 20 mg/d rosuvastatin were assigned to the observation group, and their efficacy and safety were compared and analyzed. Results The total effective rate of observation group was 96.67%, which was higher than that of control group 86.67%(P0.05). After treatment, the levels of total cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL-C) and high density lipoprotein(HDL-C) were lower in the observation group(P0.05). Conclusions The effect of 20 mg/d of rosuvastatin in the treatment of elderly CHD patients with hyperlipidemia is better than that of 10 mg/d of rosuvastatin, which can effectively regulate the level of blood lipids in the body without causing excessive adv