Rcpititative magnetic stimulation of gastrocnemius muscle evokes cerebral potentials in Duchcnnc muscular dystrophy

作     者：Cui Liying Guan Yuzhou Tang Xiaofu Li Benhong 

作者机构：Du Hua Department of neurology Peking Union Medical College I lospital Beijing 100730 China Du Hua Department of neurology Peking Union Medical College I lospital Beijing 100730 China Du Hua Department of neurology Peking Union Medical College I lospital Beijing 100730 China Du Hua Department of neurology Peking Union Medical College I lospital Beijing 100730 China 

出 版 物：《中国临床神经科学》 (Chinese Journal of Clinical Neurosciences)

年 卷 期：2000年第8卷第Z1期

页      面：89-页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：muscular dystrophy magnetic stimulation electrical stimulation evoked potentials 

摘      要：OBJECTIVE: To study the function and mechanism of the ccrebral evoked potentials by repititative stimulation of calf muscle in Duchcnne mucular dystrophy (DMD) patients with obvious muscular dystrophy and pseudohyocrtrophy. METHODS: Wc measured cerebral cvoked potcntials by stimulation of calf muscles and SEP by stimulation of posterior tibial nerves at ankle in ten patients with DMD and ten normal controls matched with sex and age. The intensity of the magnetic stimulation was at 30% of maximal output (2.1 Tcsla) and the trcquency was I Hz. The low intensity of magnetic stimulation was just sufficient to produce a contraction of the muscle belly underncath the coil. Recording electrode was placed at 2 cm posterior to the Cz. referencc to Fpz. Thc latencics of N33. P38, N48 and P55 and amplitude (P38-N48) were recorded. SEP was recorded by routine methods. RESULTS: in normal subjects. thc amplitude of magnetic stimulation of calf muscle was 40% lower. and the latency of P38 was 2.9±2.1 ms longer compared with electrical stimulation of the posterior tibial nerves at ankle. In 6 patients. P38 latency from magnetic stimulation was remarkable prolonged (P0.01). and in 4 patients. there no any response was found. SElP from electrical stimulation was normal in all patients. CONCLUSTION: DMD is an available model for the study of meclhanism of cerebral evoked potentials by magnetic stimulating muscles. Wc can coneludc that thc responses were produced by muscle input. The abnormal responses in patients may relate to decreased input of muscle by muscular dystrophy and pscudohypcrtrophy.