Systematic analysis and modeling of the FLASH sparing effect as a function of dose and dose rate

作     者：Qi-Bin Fu Yan Zhang Yu-Cheng Wang Tu-Chen Huang Hong-Yu Zhu Xiao-Wu Deng Qi-Bin Fu;Yan Zhang;Yu-Cheng Wang;Tu-Chen Huang;Hong-Yu Zhu;Xiao-Wu Deng

作者机构：Sino-French Institute of Nuclear Engineering and TechnologySun Yat-sen UniversityZhuhai 519082China Department of Radiation OncologyState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：2024年第35卷第10期

页      面：51-58页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100106[医学-放射医学] 10[医学] 

基　　金：supported by the National Key R&D Program of China(No.2022YFC2402300) National Natural Science Foundation of China(No.12075330) 

主　　题：FLASH radiotherapy Sparing effect Systematic analysis Dose rate Dose Biological endpoints 

摘      要：Ultrahigh-dose-rate radiotherapy(FLASH-RT)is a revolutionary radiotherapy technology that can spare normal tissues without compromising tumor *** qualitative experimental results have been reported,quantitative and systematic analysis of data is ***,the FLASH effect response model to the dose or dose rate is still *** study investigated the relationships between the FLASH effect and experimental parameters,such as dose,dose rate,and other factors by analyzing published in vivo experimental data from animal *** data were modeled based on logistic regression analysis using the sigmoid *** model was evaluated using prediction accuracy,receiver operating characteristic(ROC)curve,and area under the ROC *** showed that the FLASH effect was closely related to the dose,mean dose rate,tissue type,and corresponding biological *** dose rate corresponding to a 50% probability of triggering cognitive protection in the brain was 45 Gy s^(-1).The dose rate corresponding to a 50% probability of triggering intestinal crypt survival and regeneration was 140 Gy s^(-1).For the skin toxicity effect,the dose corresponding to a 50% probability of triggering the FLASH effect was 24 *** study helps to characterize the conditions underlying the FLASH effect and provides important information for optimizing experiments.