Role of long non-coding RNAs in non-alcoholic fatty liver disease

作     者：Anju Mullath Murali Krishna 

作者机构：Department of GastroenterologyAster Royal HospitalMuscat 133MuscatOman Department of UrologyArmy HospitalR&RDelhi Cantonment 110010DelhiIndia 

出 版 物：《World Journal of Meta-Analysis》 (世界荟萃分析杂志)

年 卷 期：2024年第12卷第3期

页      面：1-5页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Long noncoding RNA Non-alcoholic fatty liver disease Plasmacytoma variant translocation 1 Nuclear-enriched abundant transcript 1 Muscle-and adiposeassociated long intergenic non-coding RNA H19 

摘      要：Non-alcoholic fatty liver disease(NAFLD)is emerging as a common cause of chronic liver disease in children and *** can progress to steatohepa-titis and potentially even hepatocellular *** identification of pati-ents at risk for progressive disease is crucial for managing *** studies have identified long noncoding RNAs(lncRNAs),circular RNAs,and microRNAs as playing important roles in the pathogenesis of *** noncoding RNAs are involved in modulating several metabolic pathways such as hepatic glucose and lipid metabolism,oxidative stress,and even *** levels of lncARSR and lncRNA nuclear-enriched abundant transcript 1 have been found in patients with *** addition,lncRNAs such as PRYP4-3 and RP11-128N14.5 can distinguish patients with NAFLD from healthy *** MEG3 expression has been observed in both NAFLD and non-alcoholic steatohepatitis,suggesting that it may help predict patients at risk for disease *** advances in transcriptomics,we may discover additional targets to help in the identification and prognostication of NAFLD.