Platelet-activating factor receptor affects food intake and body weight
作者机构：Departments of Cellular and Molecular MedicineLerner Research InstituteCleveland ClinicUSA Molecular MedicineCleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityClevelandOHUSA
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2015年第2卷第3期
页 面：255-260页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This work was supported by National Institute on Alcohol Abuse and Alcoholism(NIAAA)017748
主 题：Behavior Food intake Obesity Physical activity Platelet-activating factor
摘 要：“Let’s Move!is a comprehensive initiative,launched by the First Lady,Michelle Obama,dedicates to solving problems of obesity,which is growing in *** life behaviors do affect obesity;however,the mechanistic insight in molecular level is still not *** this study,by continually monitoring mouse body weight under chow and high fat western diets as well as metabolic,physical activity and food intake behaviors assessed in a CLAMS Comprehensive Lab Animal Monitoring System,we demonstrated that the platelet-activating factor receptor(PTAFR)contributes to modification of life *** does not affect metabolism of ingested dietary fat and carbohydrate in young animals;however,Ptafr ablation dramatically increased weight gain without affecting adipose tissue ***/mice possess new habits that increased food intake and decreased *** studies suggest that regulation of PTAFR activity may be a novel strategy to control obesity in children or young adults.
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