仅有眼部症状的抗MuSK型重症肌无力
Anti-MuSK myasthenia gravis presenting with purely ocular findings作者机构：Wake Forest University School of Medicine Department of Neurology Medical Center Boulevard Winston-Salem NC 27157 United StatesDr.
出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)
年 卷 期：2005年第1卷第11期
页 面：5-5页
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
主 题：重症肌无力 MuSK 眼部症状 肌无力患者 乙酰胆碱受体 肌力减弱 放射免疫分析法 重组抗原 呼吸肌 无眼
摘 要：Background: Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) h ave been found in approximately 40%of patients with generalized myasthenia grav is who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weak ness of the neck and respiratory muscles, but patients with ocular myasthenia ha ve not been described. Objective: To report a case of ocular myasthenia due to a nti-MuSK antibodies. Patient: A young woman with ocular myasthenia and antibodi es to MuSK. Results: Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen. Conclusion: Ocular myasthenia gravis i s a presentation of the anti-MuSK antibody syndrome.
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