In search for novel strategies towards neuroprotection and neuroregeneration: is PPARα a promising therapeutic target?

作     者：Sandra Moreno Maria Paola Cerù 

作者机构：Department of Science-LIME University Roma Tre Department of Life Health and Environmental Sciences University of L’AquilaCoppito (AQ) Italy 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第9期

页      面：1409-1412页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by CAL grant to SM from University Roma Tre 

主　　题：PPAR a promising therapeutic target is PPAR 

摘      要：Peroxisome proliferator activated receptors： In the early 1990s, seminal work on rodent liver demonstrated that the hypolipidemic effect of xenobiotics, referred to as peroxisome proliferators, was mediated by a member of steroid hormone receptor superfamily, thus designated peroxisome proliferator-activated receptors （PPARs） （Issemann and Green, 1990; Dreyer et al., 1992）. The research field opened by this discovery led to the identification of three isotypes, namely PPARa （NR1C1）, PPAR[3/6 （NRIC2）, PPARy （NRIC3）, in a wide range of tissues. All these receptors act as ligand-activated transcription factors, binding lipid molecules with different, though overlapping, specificity.