Functional MRI study of mild Alzheimer＇s disease using amplitude of low frequency fluctuation analysis

作     者：XI Qian ZHAO Xiao-hu WANG Pei-jun GUO Qi-hao YAN Chao-gan HE Yong 

作者机构：Department of Radiology Tongji Hospital of Tongji UniversityShanghai 200065 China Department of Neurology Huashan Hospital of Fudan UniversityShanghai 200040 China State Key Laboratory of Cognitive Neuroscience and LearningBeijing Normal University Beijing 100875 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2012年第125卷第5期

页      面：858-862页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学] 10[医学] 

基　　金：This work was supported by grants from the National Natural Science Foundation of China (No. 30970818)  and the National High-Tech Research and Development Program of China (No. 2008AA02Z302) 

主　　题：Alzheimer's disease resting-state functional MRI amplitude of low frequency fluctuation 

摘      要：Background Previous studies have shown that the functional brain activity in the resting state is impaired in Alzheimer＇s disease （AD） patients. However, most studies focused on the relationship between different brain areas, rather than the amplitude or strength of the regional brain activity. The purpose of this study was to explore the functional brain changes in AD patients by measuring the amplitude of the blood oxygenation level dependent （BOLD） functional MRI （fMRI） signals.