Milk protein IgG and IgA:The association with milk-induced gastrointestinal symptoms in adults

作     者：Sari Anthoni Erkki Savilahti Hilpi Rautelin Kaija-Leena Kolho 

作者机构：Hospital for Children and AdolescentsUniversity of Helsinki Department of Bacteriology and ImmunologyHaartman InstituteUniversity of Helsinki and Helsinki University Central Hospital Laboratory 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2009年第15卷第39期

页      面：4915-4918页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Helsinki University Research Funds Helsinki University Central Hospital Grant and The Research Foundation for Allergy, Finland The Foundation for Promoting Occupational Medicine in Finland, Helsinki, Finland 

主　　题：Abdominal symptoms Cow's milk Food hypersensitivity 

摘      要：AIM:To study the association between serum levels of milk protein IgG and IgA antibodies and milk-related gastrointestinal symptoms in ***:Milk protein IgG and IgA antibodies were determined in serum samples of 400 subjects from five outpatient clinics in Southern *** were randomly selected from a total of 1900 adults undergoing laboratory investigations in primary *** 400 participants had completed a questionnaire on abdominal symptoms and dairy consumption while waiting for the laboratory *** questionnaire covered the nature and frequency of gastrointestinal problems,the provoking food items,family history and *** serum samples were disqualifi ed due to insuff icient amount of *** levels of specif ic milk protein IgG and IgA were measured by using the ELISA *** association of the milk protein-specific antibody level was studied in relation to the milk-related gastrointestinal symptoms and dairy ***:Subjects drinking milk(n=265) had higher levels of milk protein IgG in their sera than non-milk drinkers(n=123,P0.001).Subjects with gastrointestinal problems related to milk drinking(n=119) consumed less milk but had higher milk protein IgG levels than those with no milk-related gastrointestinal symptoms(n=198,P=0.02).Among the symptomatic subjects,those reporting dyspeptic symptoms had lower milk protein IgG levels than non-dyspeptics(P0.05).However,dyspepsia was not associated with milk drinking(P=0.5).The association of high milk protein IgG levels with constipation was close to the level of statistical signif *** had no association with milk protein IgG level(P=0.5).With regard to minor symptoms,flatulence and bloating(P=0.8),were not associated with milk protein IgG *** protein IgA levels did not show any association with milk drinking or abdominal *** levels of milk protein IgA and IgG declined as the age of the subjects increased(P0.004).CONCLUSION:Milk