受肾上腺素和巯基螯合剂影响的硫酸铜的溶血活性
Hemolytic activity of copper sulfate as influenced by epinephrine and chelating thiols作者机构：Kongsvinger Hospital 挪威 Russian Medical University 俄罗斯 Vitamin Research Institute 俄罗斯
出 版 物：《中国药理学报》 (Acta Pharmacologica Sinica)
年 卷 期：1998年第19卷第3期
页 面：203-206页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学]
摘 要：AIM:To study the effects of epinephrine, homocysteine, and other complexing agents on the cytotoxicity of copper sulfate. METHODS:In vitro suspensions of human red cells incubated with cupric sulfate were used, and hemolysis was determined by extracellular hemoglobin. RESULTS:The hemolytic activity of CuSO4 (0.3 mmol.L-1) was enhanced by the presence of epinephrine and to a lesser extent by homocysteine, whereas D-penicillamine, succimer, and mercaptodextran reduced the copper-induced hemolysis. The latter 3 chelating thiols also reduced the copper-epinephrine-induced hemolysis. The plasma protein ceruloplasmin reduced markedly the copper-epinephrine-induced hemolysis, even upon concentrations 20% of that of copper. Chromic chloride, as well, acted anti-hemolytically. CONCLUSION:The latter protectors may interact with the production or activity of toxic oxygen, while classical copper chelators sequester cupric ions from interaction with epinephrine or homocysteine.
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