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Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms

Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms

作     者:Zhi-bin LIN, Hui-na ZHANGDepartment of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100083, China 

出 版 物:《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期:2004年第11期

页      面:3-11页

核心收录:

学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主  题:Ganoderma lucidum polysaccharides triterpene immunomodulatory activities anti-tumor activities 

摘      要:Ganoderma lucidum (G lucidum) is a medicinal fungus with a variety of biological activities. It has long been used as a folk remedy for promotion of health and longevity in China and other oriental countries. The most attractive character of this kind of medicinal fungus is its immunomodulatory and anti-tumor activities. Large numbers of studies have shown that G lucidum modulate many components of the immune system such as the antigen-presenting cells, NK cells, T and B lymphocytes, The water extract and the polysaccharides fraction of G lucidum exhibited significant anti-tumor effect in several tumor-bearing animals mainly through its immunoenhancing activity. Recent studies also showed that the alcohol extract or the triterpene fraction of G lucidum possessed anti-tumor effect, which seemed to be related to the cytotoxic activity against tumor cells directly. Preliminary study indicated that antiangiogenic effect may be involved antitumor activity of G lucidum.

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