L-carnitine alleviates sciatic nerve crush injury in rats:functional and electron microscopy assessments

作     者：ümmü Zeynep Avsar Umit Avsar Ali Aydin Muhammed Yayla Berna Ozturkkaragoz Harun Un Murat Saritemur Tolga Mercantepe 

作者机构：Department of Medical EducationFaculty of MedicineAtaturk University Department of Family MedicineFaculty of MedicineAtaturk University Department of Orthopedics and TraumatologyFaculty of MedicineAtaturk University Department of PharmacologyFaculty of MedicineAtaturk University Department of PharmacologyFaculty of PharmacyAgr? University Department of BiochemistryFaculty of PharmacyAgr? University Department of Emergency MedicineFaculty of MedicineAtaturk University Department of Histology and EmbryologyFaculty of MedicineAtaturk University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2014年第9卷第10期

页      面：1020-1024页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by a grant from Ataturk University Scientific Experimental Project Office to Project Number 2012/07 

主　　题：nerve regeneration peripheral nerve injury sciatic nerve L-carnitine neuroprotection crush injury electron microscopy axon myelin sheath neural regeneration 

摘      要：Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuro-protective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved signiifcantly. These ifndings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats.