Timing of Continuous Renal Replacement Therapy Initiation in Sepsis-Associated Acute Kidney Injury: A Comprehensive Review and Future Directions

作     者：Zhengshuang Liu Chuanren Zhuang Xuehuan Wen 

作者机构：Cangnan Hospital of Traditional Chinese MedicineWenzhou 325800Zhejiang ProvinceChina The Affiliated Cangnan HospitalWenzhou Medical UniversityWenzhou 325800Zhejiang ProvinceChina 

出 版 物：《Journal of Clinical and Nursing Research》 (临床护理研究（英文）)

年 卷 期：2024年第8卷第8期

页      面：21-30页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Wenzhou Science and Technology Project(Grant No.Y2020536) 

主　　题：Sepsis Sepsis-related acute kidney injury Continuous renal replacement therapy(CRRT) Timing of initiation 

摘      要：This review examines the application of continuous renal replacement therapy(CRRT)in patients with sepsis-associated acute kidney injury(S-AKI),with a particular focus on the timing of CRRT *** review addresses the controversy surrounding initiation timing and proposes future research *** a systematic review of recent literature on CRRT for S-AKI,working principles,therapeutic mechanisms,initiation timing of CRRT,and related meta-analyses were *** studies indicate that the optimal timing for CRRT initiation in S-AKI patients remains inconclusive,with ongoing debate regarding whether early initiation significantly improves patient survival and renal *** lack of consensus reflects the heterogeneity of the S-AKI patient population and the limitations of existing research *** studies should focus on advancing the application of precision medicine in S-AKI and developing individualized treatment strategies by integrating multidimensional information to optimize CRRT utilization and improve patient outcomes.