Diet,ageing and genetic factors in the pathogenesis of diverticular disease
Diet,ageing and genetic factors in the pathogenesis of diverticular disease作者机构：Human Nutrition Research Centre School of Clinical Medical SciencesUniversity of Newcastle NE1 8RU United Kingdom Clinical Sciences Research Institute Medical School University of Warwick Coventry CV2 2DX United Kingdom Human Nutrition Research Centre School of Clinical Medical Sciences University of Newcastle NE1 8RU United Kingdom Department of Surgery Wansbeck General Hospital Northumbria NE63 9JJ United Kingdom
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2009年第15卷第20期
页 面：2479-2488页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by Food Standards Agency, N12105 Northumbria Colorectal Research Funds
主 题：Diverticular disease Dietary factors Genetics Colon Inflammation
摘 要：Diverticular disease(DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the *** high prevalence ranks it as one of the most common bowel disorders in western *** majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per *** this public health burden, relatively little seems to be known about either the mechanisms of development or *** the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressureinduced damage to the colon wall amongst those with a low intake of dietary *** this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD *** argue that the evidence supporting the barotrauma hypothesis is largely *** have also identified several gaps in the knowledge base which need to be filled before we can complete a model for the etiology of diverticular disease.
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