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Studies on Electrochemical Behavior of Bleomycin and Its Interaction with DNA at a Co/GC Ion Implantation Modified Electrode

Studies on Electrochemical Behavior of Bleomycin and Its Interaction with DNA at a Co/GC Ion Implantation Modified Electrode

作     者:胡劲波 李启隆 尚军 

作者机构:Department of Chemistry Beijing Normal University Beijing 100875 China 

出 版 物:《Chinese Journal of Chemistry》 (中国化学(英文版))

年 卷 期:2002年第20卷第3期

页      面:267-271页

核心收录:

学科分类:081704[工学-应用化学] 08[工学] 0817[工学-化学工程与技术] 

基  金:ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No.2 9875 0 0 3)andtheResearchFundfortheDoctoralPro gramofHigherEducationofChina (No .980 0 2 70 9) 

主  题:Co/GC ion implantation modified electrode linear sweep voltammetry bleomycin DNA 

摘      要:Electrochemical investigation of Bleomycin (BLM) and its interaction with DNAat a Co/GC ion implantation modified electrode was reported for the first time. The electrochemicalbehavior of BLM at Co/GC modified electrode has been studied by linear sweep and cyclicvoltammetry, The reaction of BLM with DNA formed an electrochemically nonactive complex, whichresulted in a decrease in the BLM equilibrium concentration and its reduction current. The decreasein peak current was proportional to DNA concentration and could be used to determination DNAconcentration. The equilibrium constant of DNA-BLM complex β was determined to be 5.16 x 10^(16).The experiments of AES and XPS showed that Co was surely implanted into the surface of GCE( glassycarbon electrode) and the depth distribution of Co was in good agreement with Gaussian normaldistribution; the implanted Co at GCE improved the electrocatalytic activity.

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