年龄相关性黄斑变性与日光曝晒情况、虹膜颜色以及皮肤对日光敏感性的关系
Age related macular degeneration and sun exposure, iris colour, and skin sensitivity to sunlight作者机构：Prof. Department of Medical Genetics University of Cambridge Addenbrooke’s Hospital Cambridge CB2 2QQ United Kingdom
出 版 物：《世界核心医学期刊文摘(眼科学分册)》 (Digest of the World Core Medical Journals)
年 卷 期：2006年第4期
页 面：25-25页
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
主 题：黄斑变性 虹膜 葡萄膜 日光曝晒 敏感性 皮肤 解剖部位 相关性
摘 要：Background/aim: It has been suggested that sun exposure may be a risk factor for age related macular degeneration (AMD)-and that skin sensitivity to sunlight and iris colour could be confounding factors. The aim was to investigate this further in the white population. Methods: 446 cases with end stage AMD were compared with 283 spouse controls. Data on sun exposure, places of residence, iris colour, subjective assessment of change in iris colour, hair colour at age 20, and skin sensitivity were obtained using a questionnaire. Iris colour was graded clinically by comparison with standard photographs. AMD was graded using stereoscopic colour fundus photographs as well as clinical examination and was defined as the presence of geographic atrophy or choroidal neovascularisation. All variables were included in a multiple logistic regression model including age, sex, and smoking. Results: There was no association between AMD and sun exposure or related factors except for the suggestion of an association between sunburn prone skin type and geographic atrophy which reached borderline significance. Conclusions: No significant association between AMD and sun exposure, iris colour, change in iris colour, or hair colour was demonstrated.
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