Pu-erh tea partly improved liver cholesterol metabolism disorders in colitis mice via the gut-liver axis
作者机构：College of Food Science， Southwest University Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing， Southwest University
出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康(英文))
年 卷 期：2024年
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100403[医学-营养与食品卫生学] 10[医学]
基 金：supported by the National Natural Science Foundation of China funded project (32172627) Chongqing Modern Tea Technology System for Efficient Agriculture in Mountainous Areas 2022 the Germplasm Creation Research Program of Southwest University
摘 要：Pu-erh tea has been shown to reduce gut inflammation in DSS-induced mice. Also， we found abnormal liver cholesterol metabolism in dextran sulfate sodium (DSS)-induced mice. However， it’s not clear how Pu-erh tea improves DSS-induced impaired liver cholesterol metabolism. Here， we established the DSS-induced model and clarified that DSS exacerbated gut inflammation accompanied by disorders of liver cholesterol metabolism. Pu-erh tea reshaped gut microbes， limited gut oxidative stress and inflammation (NOX2/ROS/MyD88/NF-κB， 24.97%-52.89%)， reduced gut bile acid reabsorption (up-regulation of FXR/FGF15， 24.53%-55.91%)， and promoted liver bile acid synthesis (up-regulation of PPARα/CYP7A1， 34.65%-79.14%)， thereby partly restoring liver cholesterol metabolism (regulated FXR/SHP/SREBPs， 53.19%-95.40%). Altered bile acid metabolic profiles (increased chenodeoxycholic acid， ursodeoxycholic acid， lithocholic acid， etc.) may also improve liver cholesterol metabolism by altering gut and liver inflammation. Thus， gut microbial reshaping and altered bile acid metabolism may be key targets of Pu-erh tea for improving DSS-induced liver cholesterol metabolism disorders via the gut-gut microbe-bile acid-liver axis.
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