Beta-alanine promotes angiogenesis in laser-induced choroidal neovascularization mice models
作者机构：Department of OphthalmologyShanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200080China National Clinical Research Center for Ophthalmic DiseasesShanghai 200080China National Clinical Research Center for Eye DiseasesShanghai 200080China Shanghai Key Laboratory of Fundus DiseasesShanghai 200080China Shanghai Engineering Center for Visual Science and PhotomedicineShanghai 200080China
出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)
年 卷 期：2024年第17卷第9期
页 面：1592-1598页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by the National Natural Science Foundation of China(No.82171076,No.82301221) Shanghai Municipal Education Commission(No.2023ZKZD18)
主 题：age-related macular degeneration choroidal neovascularization β-alanine angiogenesis
摘 要：AIM:To investigate the effect ofβ-alanine(BA)on laserinduced choroidal neovascularization(CNV)mice ***:Laser-induced CNV mice models were established,and BA was administrated for one week and two weeks in advance,***,retinal pigment epithelium(RPE)-choroid flat mounts were separated,and immunohistochemical staining was *** laser-induced CNV lesion areas were measured and *** addition,liver and kidney morphologies were observed to identify potential hepatorenal ***:Enlarged CNV lesion areas were observed in the BA treated *** significant differences were observed in the liver and kidney sections between ***:BA treatment increase CNV lesion areas,suggesting the detrimental effects of BA as a nutritional supplement in age-related macular degeneration(AMD)population.
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