NASOPHARYNGEAL　CARCINOMA　RADIOSENSITIVITY　PREDICTION　BY　CYTOKINESIS－BLOCK　MICRONUCLEUS　ASSAY

作     者：杨星 史剑慧 程文英 

作者机构：ShanghaiInstituteofRadiationMedicineShanghaiMedicalUniversityShanghai200032 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：1995年第6卷第1期

页      面：47-50页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100214[医学-肿瘤学] 100106[医学-放射医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Micronucleus assay Radiosensitivity Nasopharyngeal carcinoma 

摘      要：Cytokinesis-block micronucleus method is used to evaluate the radiosensitivity of a nasopharyngeal carcinoma cell line (CNE-1) and biopsies obtained from 31 patients with nasopharyngeal carcinoma. The number of micronuclei increases with theradiation dose. A good correlation was found between the radiosensitivity determined by the micro-nucleus assay and that measured by the colony-forming assay in CNE-1 cell line (r=-0.998). Moreover, the results of micronucleus assay for tumor cells from biopsies of patients with primary carcinoma look promising for the prediction of tumor radiosensitivity. These results are encouraging but fleed to be confirmed with a larger number of patients with a longer follow-up.