Danshenchuanxiongqin injection in the treatment of unstable angina pectoris: a systematic review and Meta-analysis

作     者：Zhang Xiaomeng Wu Jiarui Zhang Bing Zhou Wei 

作者机构：Department of Clinical Pharmacy of Traditional Chinese Medicine School of Chinese Materia Medica Beijing University of Chinese Medicine 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2016年第36卷第2期

页      面：144-150页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China(Study on the Key Factors of Allergic Reaction that Caused by Chinese Herbal Injection Based on the Three-Dimensional Database and Multi-Dimensional Data-Mining,No.81473547) Scientific Research Innovation Team Project of Beijing University of Chinese Medicine(the Basic Theory of Traditional Chinese Medicine,No.2011-CXTD-14) 

主　　题：Danshenchuanxiongqin injection An gina unstable Review Meta-analysis 

摘      要：OBJECTIVE:To evaluate systematically the efficacy and safety of Danshenchuanxiongqin Injection(DCI)in the treatment of unstable angina pectoris(UAP).METHODS:Randomized controlled trials(RCTs)regarding DCI used for treating UAP were searched in English and Chinese electronic databases from inception to January *** reviewers independently retrieved RCTs and extracted relevant *** Cochrane risk of bias method was used to assess the quality of included studies,and a Meta-analysis was conducted with Review Manager5.2 ***:Eleven RCTs involving 1034 participants were *** methodological quality was relatively *** Meta-analysis indicated that the combined use of DCI and conventional treatment with Western Medicine(WM)was more efficacious in the outcomes of total effective rate[Relative Risk(RR)=1.27,95%CI(confidence interval;1.18,1.35),P0.000 01],the total effective rate of ECG[RR=1.40,95%CI(1.18,1.66),P0.000 01],total cholesterol[Mean difference(MD)=-0.58,95%CI(-0.83,-0.33),P0.000 01],total triglycerides[MD=-0.36,95%CI(-0.54,-0.17),P=0.0001],and the number of ST-segment depression[MD=-0.36,95%CI(-0.54,-0.17),P=0.0001].There were two adverse drug reactions reported in one ***:Based on the systematic review,DCI combined with WM appeared to be efficacious in the treatment ***,the evidence of DCI for treating UAP requires large-scale and double-blind RCTs to substantiate these findings.