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An Interspecies Conserved Antigen of Plasmodium falciparum Containing Clusters of Asparagine Residues

An Interspecies Conserved Antigen of Plasmodium falciparum Containing Clusters of Asparagine Residues

作     者:Ma Donghui Li Xiaojie Ma Huiwen Fred A. S. Kironde 

作者机构:Wuhan University College of Life Sciences Wuhan China (GRID:grid.49470.3e) (ISNI:***) Shaheed Jeet Singh Marg International Center for Genetic Engineering and Biotechnology New Delhi India (GRID:grid.425195.e) (ISNI:0000 0004 0498 7682) 

出 版 物:《Wuhan University Journal of Natural Sciences》 (武汉大学学报(自然科学英文版))

年 卷 期:1998年第3卷第3期

页      面:115-122页

学科分类:1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

主  题:Plasmodium falciparum asparagine rich proteins,interspecies conserved antigens 

摘      要:An interspecies conserved Plasmodium asparagine rich antigen, designated as ARK26, was isolated by immunoscreening *** genomic DNA expression library with mouse convalescent anti *** serum. Partial DNA sequence analysis reveals that ARK26 contains clusters of asparagines and no randomly repeated amino acid sequence motifs are observed. A 65 ×10 3 GST fusion protein is expressed by recombinant plasmid PGEX 5X 1(ARK26) in *** C strain ABLE K. Computer programs predict that two asparagine rich regions are among the possible antigenic epitopes of p37 encoded by ARK26. Interestingly, the sequence of ARK26 displays significant similarity to yeast and several other species mitochondrial genes, and its possible function is discussed.

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