Significance of alpha-fetoprotein mRNA level in hepatocellular carcinoma patients treated with radiofrequency ablation

作     者：Du, Xi-Lin Ma, Qing-Jiu Wu, Tao Bao, Guo-Qiang Lu, Jian-Guo Chu, Yan-Kui 

作者机构：Fourth Mil Med Univ Dept Gen Surg Tangdu Hosp Xian 710038 Peoples R China 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2007年第6卷第2期

页      面：172-175页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：aFPmRNA radiofrequency ablation carcinoma, hepatocellular RT-PCR 

摘      要：BACKGROUND: Many methods are used to treat liver cancer. Among them, radiofrequency ablation (RFA) is a hot topic because of its advantages. This study was designed to determine the significance of blood alpha-fetoprotein mRNA (AFPmRNA) changes in patients with hepatocellular carcinoma (HCC) treated with RFA. METHODS: The AFPmRNA content in blood samples from HCC patients was determined by reverse transcriptase-polymerase chain reaction (RT-PCR) before RFA and 48 hours, 72 hours, I week and 2 weeks later. RESULTS: The blood of 183 patients was negative for AFPmRNA before REA, but that of 62 of them was positive 72 hours later, then returned to negative after 2 weeks. The blood of 129 patients was positive for AFPmRNA before RFA, but that of 112 of them became negative 2 weeks later; 17 patients were still AFPmRNA positive 2 weeks after REA. CONCLUSIONS: Blood AFPmRNA, which is increased temporarily after RFA, can be used as an objective index for the persistence and recurrence of HCC after REA.