黄花三宝木中高度芳香化的降二萜异源二聚体及其单体（英文）
作者机构：State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery
出 版 物：《Engineering》 (工程(英文))
年 卷 期：2024年第7期
页 面：144-154页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学]
基 金：The financial support from the National Natural Science Foundation of China (22237007 and 22177122) the Biological Resources Program of Chinese Academy of Sciences (CAS)(KFJ-BRP-008-001) the Youth Innovation Promotion Association of Chinese Academy of Sciences (2022282)
摘 要：Four new norditerpenoid heterodimers with different dimerization patterns-namely,trigofragiloids A–C(denoted as compounds 1–3) and (+)-and (—)-trigofragiloid D (compound 4)-and three new phenanthrenone norditerpenoids-namely,trigofragiloids E–G (compounds 5–7)-were isolated from Trigonostemon *** 1 and 2 feature a novel heterodimeric carbon skeleton formed by the conjugation of a tetra-norditerpenoid and an ennea-norditerpenoid;they have been identified as class 2 atropisomers by means of quantum chemical *** 3 is an unprecedented phenylpropanoid–norditerpenoid adduct with a new dimerization *** (+)-and (—)-4are the first example of S-shaped 1,4-dioxane-fused norditerpenoid *** by the structure elucidation of compound 4,two co-occurring analogues,actephilol A and epiactephilol A,were structurally revised as a pair of geometrical isomers and were identified as two pairs of enantiomers,(+)-and (—)-8and (+)-and (—)-9,*** structures were characterized using a combined ***,compound 7 exhibits remarkable adenosine triphosphate-citrate lyase (ACLY) inhibition with a halfmaximal inhibition concentration (IC50) value of (0.46±0.11)μmol·L—1,as active as the positive control BMS-303141,and a molecular docking study offers deep insight into the interaction between compound7 and ACLY.
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