Signal intensity changes of dentate nucleus on plain MR T1WI innasopharyngeal carcinoma patients after radiotherapy andmultiple injections of gadolinium-base contrast agent

作     者：SUN Jiping ZHOU Jian TAO Zhigang LIANG Jiafeng DING Zhongxiang 孙继平;周健;陶志刚;梁佳凤;丁忠祥

作者机构：Department of RadiologyHangzhou Cancer HospitalHangzhou 310002China Department of RadiotherapyHangzhou Cancer HospitalHangzhou 310002China Department of RadiologyHangzhou First People's Hospital Affiliated to Westlake University School of MedicineHangzhou 310003China 

出 版 物：《中国医学影像技术》 (Chinese Journal of Medical Imaging Technology)

年 卷 期：2024年第40卷第8期

页      面：1170-1173页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100214[医学-肿瘤学] 10[医学] 

基　　金：浙江省基础公益研究计划项目(LY22H180008) 

主　　题：nasopharyngeal neoplasms radiotherapy contrast media cerebellar nuclei 

摘      要：Objective To observe changes of plain MR T1WI signal intensity of dentate nucleus in nasopharyngeal carcinoma patients after radiotherapy and multiple times of intravenous injection of gadolinium-based contrast agent(GBCA).Methods Fifty patients with pathologically confirmed nasopharyngeal carcinoma and received intensity-modulated radiotherapy were retrospectively enrolled as the nasopharyngeal carcinoma group,and 50 patients with other malignant tumors and without history of brain radiotherapy were retrospectively enrolled as the control *** patients received yearly GBCA enhanced MR examinations for the nasopharynx or the head.T1WI signal intensities of the dentate nucleus and the pons on same plane were measured based on images in the year of confirmed diagnosis(recorded as the first year)and in the second to the fifth years.T1WI signal intensity ratio of year i(ranging from 1 to 5)was calculated with values of dentate nucleus divided by values of the pons(ΔSI i),while the percentage of relative changes of year j(ranging from 2 to 5)was calculated withΔSI j compared toΔSI 1(Rchange j).The values of these two parameters were compared,and the correlation ofΔSI and GBCA injection year-time was evaluated within each *** No significant difference of gender,age norΔSI 1 was found between groups(all P0.05).The second to the fifth yearΔSI and Rchange in nasopharyngeal carcinoma group were all higher than those in control group(all P0.05).Within both groups,ΔSI was positively correlated with GBCA injection year-time(both P0.05).Conclusion Patients with nasopharyngeal carcinoma who underwent radiotherapy and multiple times of intravenous injection of GBCA tended to be found with gradually worsening GBCA deposition in dentate nucleus,for which radiotherapy might be a risk factor.