Is deep brain imaging on the brink of transformation with a bioluminescence molecule?

作     者：Shumao Xu Farid Manshaii Jun Chen Shumao Xu;Farid Manshaii;Jun Chen

作者机构：Department of BioengineeringUniversity of CaliforniaLos AngelesLos AngelesUSA 

出 版 物：《BMEMat(BioMedical Engineering Materials)》 (生物医学工程材料（英文）)

年 卷 期：2024年第2卷第3期

页      面：4-8页

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：University of California, Los Angeles, UCLA Brain and Behavior Research Foundation, BBRF, (30944) Brain and Behavior Research Foundation, BBRF Office of Naval Research, ONR, (N00014‐24‐1‐2065) Office of Naval Research, ONR National Institutes of Health, NIH, (R01 CA287326) National Institutes of Health, NIH American Heart Association, AHA, (23IPA1054908, 23TPA1141360, 23SCEFIA1157587) American Heart Association, AHA NIH National Center for Advancing Translational Science UCLA CTSI, (KL2TR001882) 

主　　题：bioluminescence molecule blood-brain barrier brain imaging 

摘      要：Cephalofurimazine(CFz),when paired with Antares luciferase,shows superior blood-brain barrier permeability and enhanced imaging depth and clarity for deep brain *** bioluminescence provides a less invasive method for real-time monitoring of deep brain activity,with the potential to advance targeted therapies and deepen our understanding of brain *** molecular engineering and localized delivery can reduce the potential toxicity of CFz and enhance its efficacy for clinical deep brain imaging.