The Chinese skeleton: insights into microstructure that help to explain the epidemiology of fracture

作     者：Elaine Cong Marcella D Walker 

作者机构：New York Presbyterian Hospital 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2014年第2卷第2期

页      面：80-92页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by NIH grants K23 AR053507  a National Osteoporosis Foundation grant  and the Mary and David Hoar Fellowship Program of the New York Community Trust and the New York Academy of Medicine 

主　　题：bone insights into microstructure that help to explain the epidemiology of fracture The Chinese skeleton 

摘      要：Osteoporotic fractures are a major public health problem worldwide, but incidence varies greatly across racial groups and geographic regions. Recent work suggests that the incidence of osteoporotic fracture is rising among Asian populations. Studies comparing areal bone mineral density and fracture across races generally indicate lower bone mineral density in Asian individuals including the Chinese, but this does not reflect their relatively low risk of non-vertebral fractures. In contrast, the Chinese have relatively high vertebral fracture rates similar to that of Caucasians. The paradoxically low risk for some types of fractures among the Chinese despite their low areal bone mineral density has been elucidated in part by recent advances in skeletal imaging. New techniques for assessing bone quality non-invasively demonstrate that the Chinese compensate for smaller bone size by differences in hip geometry and microstructural skeletal organization. Studies evaluating factors influencing racial differences in bone remodeling, as well as bone acquisition and loss, may further elucidate racial variation in bone microstructure. Advances in understanding the microstructure of the Chinese skeleton have not only helped to explain the epidemiology of fracture in the Chinese, but may also provide insight into the epidemiology of fracture in other races as well.