Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue

作     者：WU LiZhen ZHOU LinKang CHEN Cheng GONG JingYi XU Li YE Jing LI De LI Peng 

作者机构：MOE key laboratory of Bioinformatics and Tsinghua-Peking Center for Life Sciences School of Life Sciences Tsinghua University Department of Biology Hong Kong University of Science and Technology Key Laboratory for Feed Biotechnology of the Ministry of AgricultureFeed Research Institute Chinese Academy of Agricultural Sciences Department of Pathology The Fourth Military Medical University Center of Biomedical Analysis Tsinghua University 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2014年第57卷第1期

页      面：107-116页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the National Basic Research Program(2013CB530602 and 2011CB910801 to Li Peng) the National Natural Science Foundation of China(30925017,31030038 and 90913024) the China Postdoctoral Science Foundation(2012M520249 and 2013T60103 to Zhou LinKang) 

主　　题：Cidea Fsp27 brown adipose tissue white adipose tissue lipid droplet fusion 

摘      要：Excess lipid storage in adipose tissue results in the development of obesity and other metabolic disorders including diabetes,fatty liver and cardiovascular *** lipid droplet(LD)is an important subcellular organelle responsible for lipid *** previously observed that Fsp27,a member of the CIDE family proteins,is localized to LD-contact sites and promotes atypical LD fusion and ***,a close homolog of Fsp27,is expressed at high levels in brown adipose ***,the exact role of Cidea in promoting LD fusion and lipid storage in adipose tissue remains ***,we expressed Cidea in Fsp27-knockdown adipocytes and observed that Cidea has similar activity to Fsp27 in promoting lipid storage and LD fusion and ***,we generated Cidea and Fsp27 double-deficient mice and observed that these animals had drastically reduced adipose tissue mass and a strong lean *** addition,Cidea/Fsp27 double-deficient mice had improved insulin sensitivity and were intolerant to ***,we observed that the brown and white adipose tissues of Cidea/Fsp27double-deficient mice had significantly reduced lipid storage and contained smaller LDs compared to those of Cidea or Fsp27single deficient ***,these data reveal an important role of Cidea in controlling lipid droplet fusion,lipid storage in brown and white adipose tissue,and the development of obesity.