The efficacy of the inhalation of an aerosolized Group A streptococcal preparation in the treatment of lung cancer

作     者：Jun Liu Xiang Liu Fei Cui Guoqin Chen Yubao Guan Jianxing He 

作者机构：Department of Cardiothoracic SurgeryThe First Affiliated Hospital of Guangzhou Medical College Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease Southern Medical UniversityGuangzhouPeople's Republic of China The Second Affiliated Hospital of South China UniversityHengyangPeople's Republic of China Department of RadiologyThe First Affiliated Hospital of Guangzhou Medical College 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2012年第24卷第4期

页      面：346-352页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Group A streptococcal （GAS） lung cancer Lewis lung carcinoma cell 

摘      要：Objective： To observe the efficacy of the inhalation of an aerosonzeo group ~ sueloto^u v / preparation in treating orthotopic lung cancer in mouse models and assess the feasibility, safety, and effectiveness of this administration mode for lung cancer. Methods： Lewis lung carcinoma （LLC） cell strains were administered via intrathoracic injection to establish orthotopic lung cancer mouse models. After the tumor-bearing models were successfully established, as confirmed by computed tomography, the mice were administered by inhalation with an aerosolized GAS preparation （GAS group） or aerosolized normal saline （control group）. The anti-tumor effect of the aerosolized GAS preparation was evaluated histologically; meanwhile, the survival and quality of life were compared between these two groups. Results： The aerosolized GAS preparation showed remarkably anti-tumor effect, causing the necrosis of the orthotopic lung cancer cells in tumor-bearing mice. Furthermore, mice in the GAS group had significantly better qualitT of life and longer survival than those in control group. Conclusions： The inhalation of aerosolized GAS preparation may be a feasible, safe and effective solution for lung cancer