Loss of membranous carcinoembryonic antigen-related cell adhesion molecule 1 expression is related to decreased relapse-free survival of hepatocellular carcinoma following liver transplantation

作     者：SHA Qing-quan WEI Qi-zhen ZHU Jian-kan WANG Ke-xin WANG Chao LIU Hai-tao YU Wen-bin LI Ming-xia ZHANG Guang-yong 

作者机构：Department of Clinical Medicine Shandong University School of Medicine Jinan Shandong 250012 China Department of General Surgery Qilu Hospital of Shandong University Jinan Shandong 250012 China First People's Hospital of Ningyang County Tai'an Shandong 271400 China School of Chemistry Shandong University Jinan Shandong 250012 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2012年第125卷第16期

页      面：2841-2845页

核心收录：

学科分类：07[理学] 

主　　题：carcinoembryonic antigen-related cell adhesion molecule 1 hepatocellular carcinoma,"liver transplantation," recurrence 

摘      要：Background Loss of carcinoembryonic antigen-related cell adhesion molecule 1 （CEACAM1） expression is an adverse prognostic factor in hepatocellular carcinoma （HCC）. The purpose of this study was to investigate the expression of CEACAM1 and its effect on relapse-free survival （RFS） following liver transplantation （LT） for HCC. Methods Expression of CEACAM1 was immunohistochemically detected in HCC specimens from 48 patients. The relationship between CEACAM1 expression and clinicopathologic variables, as well as tumor recurrence, was further analyzed. Results Of the 48 HCC specimens, membranous CEACAM1 expression was detected in 25 specimens and cytoplasmic CEACAM1 expression was detected in 19 specimens. Four specimens had loss of CEACAM1 expression. Loss of membranous CEACAM1 expression was significantly associated with tumor size, tumor number, and serum （z-fetoprotein levels （all P 〈0.05）. Patients with loss of membranous CEACAM1 had significantly poorer RFS than patients with membranous expression, determined via Kaplan-Meier analysis （P=0.027）. Multivariate analysis revealed that loss of membranous CEACAM1 expression might be an independent prognostic factor of RFS for HCC patients after liver transplantation （P=0.037）. Conclusion Loss of membranous CEACAM1 expression in HCC was closely associated with aggressive tumor biology and might be a relapsing biomarker of HCC treated with LT.