Methodology for high-quality studies on course and prognosis of inflammatory bowel disease

作     者：Irene Modesto Giovanni Perricone Ambrogio Orlando Mario Cottone 

作者机构：Division of Internal Medicine"Villa SofiaCervello" HospitalUniversity of Palermo790146 PalermoItaly 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第29期

页      面：3800-3805页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Methodology Inflammatory bowel disease course Prognosis Population based studies Prospective cohort studies 

摘      要：Inflammatory bowel diseases(IBDs) are characterized by a chronic course with an alternation of relapses and *** about prognosis are important for the patient who wants to know how the disease will affect his/her life and also for clinicians to make management *** selection of the patients is the basis for good methodological studies on the course of IBD.A great proportion of data on the course of IBD is derived from a limited number of cohort *** help to define the endpoints for clinical trials and to identify subsets of patients in whom the prognosis of the disease can be stratified according to clinical *** scientific requirements for high-quality studies on prognosis are the following:use of inception cohort,description of referral patterns,completeness of follow-up,objective outcome criteria,blind outcome assessment,adjustment for extraneous prognostic factors and statistical *** analyzed each of these requirements in studies on *** date,prospective and populationbased cohort studies are the standard for an unbiased assessment of prognosis.A better knowledge of the course of disease of chronic disorders ideally requires:(1) data from population-based studies,to avoid selection bias from referral centers in which patients with a more severe disease are usually treated;(2) inclusion of patients seen at the onset of the disease excluding misdiagnosed cases;and(3) follow-up from the onset of the disease to the end without dropouts.