The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer

作     者：Kun Li Bo Yang Yingying Du Yi Ding Shihui Shen Zhengwang Sun Yun Liu Yuhan Wang Siyuan Cao Wenjie Ren Xiangyu Wang Mengjuan Li Yunpeng Zhang Juan Wu Wei Zheng Wangjun Yan Lei Li Kun Li;Bo Yang;Yingying Du;Yi Ding;Shihui Shen;Zhengwang Sun;Yun Liu;Yuhan Wang;Siyuan Cao;Wenjie Ren;Xiangyu Wang;Mengjuan Li;Yunpeng Zhang;Juan Wu;Wei Zheng;Wangjun Yan;Lei Li

作者机构：Department of Musculoskeletal OncologyFudan University Shanghai Cancer CenterShanghai 200032China Health Science CenterEast China Normal UniversityShanghai 200241China Chongqing Key Laboratory of Precision OpticsChongqing Institute of East China Normal UniversityChongqing 401120China School of Life SciencesEast China Normal UniversityShanghai 200241China Joint Center for Translational MedicineShanghai Fifth People’s HospitalFudan University and School of Life ScienceEast China Normal UniversityShanghai 200240China Department of Pharmacy The General Hospital of Western Theater CommandChengdu 610083China Orthopaedic Department of Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Department of OrthopedicsGeneral Hospital of Western Theater CommandChengdu 610000China College of MedicineSouthwest Jiaotong UniversityChengdu 610031P.R.China 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2024年第12卷第3期

页      面：704-719页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：sponsored by National Natural Science Foundation of China (82303396,82022051,82072972 and 81672883) Science and Technology Commission of Shanghai (22YF1408400) Shanghai Pilot Program for Basic Research (TQ20240208) Natural Science Foundation of Chongqing (CSTB2024NSCQ-JQX0009 and CSTB2024NSCQ-MSX0594) The Postdoctoral Foundation of China (2023T160122) Anti-cancer Association in Shanghai,Joint Foundation from Fudan University Shanghai Cancer Center (YJQN202102) Science&Techenology Department of Sichuan Province (2023NSFSC0705) the Fund of major military joint research project (2019LH 02) Shanghai municipal hospital emerging frontier joint research project (SHDC12024112) 

主　　题：metastasis NOD1 HOX 

摘      要：While KRAS mutation is the leading cause of low survival rates in lung cancer bone metastasis patients,effective treatments are still ***,we identified homeobox C10(HOXC10)as a lynchpin in pan-KRAS-mutant lung cancer bone metastasis.