Resistance mechanisms and potential therapeutic strategies in relapsed or refractory natural killer/T cell lymphoma

作     者：Wang Chengji Wang Liang Chengji Wang;Liang Wang

作者机构：Department of Hematology Beijing Tongren Hospital Capital Medical University Beijing China 

出 版 物：《中华医学杂志(英文版)》 (Chinese Medical Journal)

年 卷 期：2024年第137卷第19期

页      面：2024 Aug 23页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was funded by Beijing Physician Scientist Training Project to Liang Wang.(No. BJPSTP-2024-01) 

主　　题：Natural killer/T cell lymphoma Epstein–Barr virus Chemotherapy resistance Asparaginase Immunotherapy 

摘      要：Natural killer/T cell lymphoma (NKTCL) is a malignant tumor originating from NK or T cells, characterized by its highly aggressive and heterogeneous nature. NKTCL is predominantly associated with Epstein–Barr virus infection, disproportionately affecting Asian and Latin American populations. Owing to the application of asparaginase and immunotherapy, clinical outcomes have improved significantly. However, for patients in whom first-line treatment fails, the prognosis is exceedingly poor. Overexpression of multidrug resistance genes, abnormal signaling pathways, epigenetic modifications and active Epstein–Barr virus infection may be responsible for resistance. This review summarized the mechanisms of resistance for NKTCL and proposed potential therapeutic approaches.