Arabidopsis Mutants and the Network of M icrotu bu le-Associated Functions
Arabidopsis Mutants and the Network of M icrotu bu le-Associated Functions作者机构：Department of Cell and Developmental Biology John Innes Centre 1 Colney Lane Norwich NR4 7UH UK
出 版 物：《Molecular Plant》 (分子植物（英文版）)
年 卷 期：2008年第1卷第6期
页 面：888-898页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种]
主 题：cell division cell morphogenesis cytoskeleton genetics development Arabidopsis.
摘 要：In early eukaryotes, the microtubule system was engaged in mitosis, intracellular transport, and flagellumbased motility. In the plant lineage, the evolution of a multicellular body involved the conservation of some core functions, the loss of others, and the elaboration of new microtubule functions associated with the multicellular plant habit. This diversification is reflected by the presence of both conserved （animal/fungi-like） and novel （plant-like） sequences encoding microtubule-related functions in the Arabidopsis genome. The collection of microtubule mutants has grown rapidly over recent years. These mutants present a wide range of phenotypes, consistent with the hypothesis of a functional diversification of the microtubule system. In this review, we focus on mutant analysis and, in particular, discuss double mutant analysis as a valuable tool for pinpointing pathways of gene function. A future challenge will be to define the complete network of genetic and physical interactions of microtubule function in plants. In addition to reviewing recent progress in the functional analysis of the ＇MAPome＇, we present an online database of Arabidopsis mutants impaired in microtubule functions.
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