Impact of antiviral therapy on post-hepatectomy outcome for hepatitis B-related hepatocellular carcinoma
Impact of antiviral therapy on post-hepatectomy outcome for hepatitis B-related hepatocellular carcinoma作者机构：Division of Hepato-biliary and Pancreatic Surgery Department of Surgery Prince of Wales Hospital the Chinese University of Hong Kong Institute of Digestive Disease and Department of Medicine and Therapeutics Prince of Wales Hospital the Chinese University of Hong Kong
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2014年第20卷第20期
页 面：6006-6012页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Antiviral therapy Hepatitis B infection Hepatocell
摘 要：The outcome after curative resection for hepatocellular carcinoma(HCC)remains unsatisfactory due to the high recurrence rate after *** patients with hepatitis B virus(HBV)-related HCC,which is the majority of patients with HCC in Asia,a high viral load is a strong risk factor for HCC *** is logical to believe that antiviral therapy may improve the postoperative outcome by promoting viral clearance and hepatocyte regeneration,as well as improving residual liver volume in HCC patients with hepatitis ***,the effect of antiviral therapy on clinical outcomes after liver resection in patients with HBV-related HCC remains to be *** are two main groups of antiviral treatment for HBV-oral nucleos(t)ide analogues and *** treatment reduces the overall incidence of HBV-related HCC in sustained ***,side effects may limit its long-term clinical ***(t)ide analogues carry fewer side effects and are potent in terms of viral suppression when compared to interferon and are typically implemented for patients with more advanced liver *** may also improve the outcome after curative resection for HBV-related *** are increasing evidence to suggest that antiviral therapy could suppress HBV,decrease the perioperative reactivation of viral replication,reduce liver injury,preserve the liver function before and after operation,and may lower the risk of HCC *** all,antiviral therapy may improve the survival after liver resection by reducing recurrence and delaying the liver damage by the virus,resulting in a higher chance of receiving aggressive salvage therapy during HCC recurrence.
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