The role of Nkx3.2 in chondrogenesis
The role of Nkx3.2 in chondrogenesis作者机构：Department of Integrative Physiology and Pathobiology Tufts University School of Medicine 136 Harrison Avenue Boston MA 02111 USA Program in Cellular Molecular and Developmental Biology Sackler School of Graduate Biomedical Sciences Tufts University 136 Harrison Avenue Boston MA 02111 USA Department of Orthopaedics Tufts Medical Center 800 Washington Street Boston MA 02111 USA
出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)
年 卷 期：2014年第9卷第5期
页 面：376-381页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 071002[理学-动物学]
主 题：Nkx3.2 musculoskeletal development chondrogenesis chondrocyte hyperlxophy
摘 要：Transcription factor, Nkx3.2, is a member of the NK family of developmental genes and is expressed during embryogenesis in a variety of mammalian model organisms, including chicken and mouse. It was first identified in Drosophila as the Bagpipe （bap） gene, where it has been demonstrated to be essential during formation of the midgut musculature. However, mammalian homolog Nkx3.2 has been shown to play a significant role in axial and limb skeletogenesis; in particular, the human skeletal disease, spondylo-megaepiphyseal-metaphyseal dysplasia （SMMD）, is associated with mutations of the Nkx3.2 gene. In this review, we highlight the role of Nkx3.2 during musculoskeletal development, with an emphasis on the factor＇s role in determining chondrogenic cell fate and its subsequent role in endochondral ossification and chondrocyte survival.
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