Stress relaxation analysis of single chondrocytes using porohyperelastic model based on AFM experiments

作     者：Trung Dung Nguyen Adekunle Oloyede Yuantong Gu 

作者机构：School of ChemistryPhysics and Mechanical EngineeringScience and Engineering FacultyQueensland University of Technology 

出 版 物：《Theoretical & Applied Mechanics Letters》 (力学快报（英文版）)

年 卷 期：2014年第4卷第5期

页      面：74-80页

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by ARC Future Fellowship Project(FT100100172) QUT Postgraduate Research Scholarship 

主　　题：cell biomechanics chondrocytes atomic force microscopy stress relaxation,porohyperelastic (PHE) constitutive model 

摘      要：Based on atomic force microscopy technique, we found that the chon- drocytes exhibits stress relaxation behavior. We explored the mechanism of this stress relaxation behavior and concluded that the intracellular fluid exuding out from the cells during deformation plays the most important role in the stress relax- ation. We applied the inverse finite element analysis technique to determine nec- essary material parameters for porohyperelastic （PHE） model to simulate stress relaxation behavior as this model is proven capable of capturing the non-linear behavior and the fluid-solid interaction during the stress relaxation of the single chondrocytes. It is observed that PHE model can precisely capture the stress re- laxation behavior of single chondrocytes and would be a suitable model for cell biomechanics.