Dual role of phage terminase in Salmonella enterica oxidative stress response

作     者：Senfeng Zhang Shengsheng Ma Feizuo Wang Chunyi Hu 

作者机构：Department of Biological SciencesFaculty of ScienceNational University of SingaporeSingapore 117543Singapore Department of BiochemistryYong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Precision Medicine Translational Research Programme(TRP)Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore 

出 版 物：《Engineering Microbiology》 (工程微生物学（英文）)

年 卷 期：2024年第4卷第3期

页      面：67-69页

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

主　　题：Phage Terminase Oxidative stress tRNA SOS response 

摘      要：The adaptive survival mechanisms of bacterial pathogens under host-induced stress are crucial for understanding ***,Uppalapati et *** a unique dual function of the Gifsy-1 prophage terminase in Salmonella enterica:it acts as a transfer ribonuclease(tRNase)under oxidative *** Gifsy-1 prophage terminase targets and fragments tRNALeu to halt translation and temporarily impairs bacterial growth when exposed to high levels of ROS generated by the host immune *** response not only preserves genomic integrity by facilitating DNA repair but also inhibits prophage mobilization,thereby aiding in bacterial survival within vertebrate *** study highlights a novel intersection between phage biology and bacterial adaptive strategies.