BAK1 Directly Regulates Brassinosteroid Perception and BRI1 Activation

作     者：Kai He Shengbao Xu Jia Li 

作者机构：Ministry of Education Key Laboratory of Cell Activities and Stress AdaptationsSchool of Life SciencesLanzhou University 

出 版 物：《Journal of Integrative Plant Biology》 (植物学报（英文版）)

年 卷 期：2013年第55卷第12期

页      面：1264-1270页

核心收录：

学科分类：0710[理学-生物学] 071001[理学-植物学] 07[理学] 0901[农学-作物学] 0703[理学-化学] 0902[农学-园艺学] 

基　　金：supported by the grants from the National Natural Science Foundation of China to J.L.(91117008 and 90917019) National Basic Research Program of China to J.L.(2011CB915401) Fundamental Research Funds for the Central Universities to S.X.(lzujbky-2009-35) 

主　　题：Arabidopsis BAK1 brassinosteroid BRI1 co-receptor extracellular domain leucine-rich repeat receptor receptor-like kinase. 

摘      要：Plants utilize plasma membrane-localized receptor-like kinases （RLKs） to sense extracellular signals to coordinate growth, development, and innate immune responses. BAK1 regulates multiple signaling pathways acting as a co-receptor of several distinct ligand-binding RLKs. It has been debated whether BAK1 serves as an essential regulatory component or only a signal amplifier without pathway specificity. This issue has been clarified recently. Genetic and structural analyses indicated that BAK1 and its homologs play indispensible roles in mediating brassinosteroid （BR） signaling pathway by directly perceiving the ligand BR and activating the receptor of BR, BRII. The mechanism revealed by these studies now serves as a paradigm for how a pair of RLKs can function together in ligand binding and subsequent initiation of signaling.