Protein Interactome Analysis for Countering Pathogen Drug Resistance

作     者：Limsoon Wong Guimei Liu 

作者机构：School of Computing National University of Singapore 

出 版 物：《Journal of Computer Science & Technology》 (计算机科学技术学报（英文版）)

年 卷 期：2010年第25卷第1期

页      面：124-130页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported in part by Singapore National Research Foundation under Grant No. NRF-G-CRP-2997-04-082(d) 

主　　题：protein complexes protein interactomes drug resistance infectious diseases 

摘      要：Drug-resistant varieties of pathogens are now a recognized global threat. Insights into the routes for drug resistance in these pathogens are critical for developing more effective antibacterial drugs. A systems-level analysis of the genes, proteins, and interactions involved is an important step to gaining such insights. This paper discusses some of the computational challenges that must be surmounted to enable such an analysis; viz., unreliability of bacterial interactome maps, paucity of bacterial interactome maps, and identification of pathways to bacterial drug resistance.