新生儿重症监护病房内腺病毒30型的暴发流行

作     者：Faden H. Wynn R.J. Campagna L. Ryan R.M. 平智广 

作者机构：Department of Pediatrics SUNY School of Medicine at Buffalo Women Children's Hosp. of Buffalo 219 Bryant Street Buffalo NY 14222 United States Dr. 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2005年第1卷第8期

页      面：35-36页

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：腺病毒肺炎 婴儿死亡 感染控制措施 固醇类药物 腺病毒感染 重症监护 机械通气 无症状感染 潜在可能性 发育不良 

摘      要：Objectives: To describe an outbreak of adenovirus, type 30, in a neonatal int ensive care unit (NICU). Study design: This was a retrospective, observational s tudy. Results: An outbreak of adenovirus infection occurred in an NICU. It laste d 6 months and involved 21 of 333 (6.3% ) infants. The introduction of infectio n control measures controlled the outbreak; however, premature discontinuation o f the measures resulted in a second wave of cases. The virus caused pneumonia in 7 infants, conjunctivitis in 7 infants, pneumon ia and conjunctivitis in 1 infant, and upper respiratory tract illness in 1 infa nt. Infection was asymptomatic in 5 infants. Six infants died. Death was associa ted with the presence of pneumonia (P = .0001), administration of steroids (P = .003), and mechanical ventilation (P = .02). Investigation into the origin of th e outbreak suggested that the virus may have been introduced and spread during o phthalmologic procedures. Conclusions: Adenovirus type 30 can cause severe disea se among premature infants in an NICU. Infants with severe bronchopulmonary dysp lasia requiring mechanical ventilation are more likely to have development of ad enovirus pneumonia and die. Standard infection control measures are effective in controlling an outbreak. Ophthalmologic procedures continue to be a potential s ource of adenovirus outbreaks.